Wayne might need to lean on that knowledge a bit in the future.
Luck played for two seasons at Stanford under new Indianapolis offensive coordinator Pep Hamilton, and he said earlier this spring that about 75 percent of the system being installed is familiar from his college days.
Wayne still is catching up with some of the finer points of the scheme. He said some things are similar to last year's offense under Bruce Arians, who left to become the head coach of the Arizona Cardinals. Others are unlike anything he's been asked to do in his previous 12 seasons in the NFL.
Wayne is here for the final week of OTAs, in part, so he can hear Luck call plays in the huddle, hear Hamilton describe them in meetings and get a little better feel for the terminology.
But Luck believes the six-time Pro Bowl selection ultimately will make a smooth transition.
"Reggie's going to look great in whatever offense you put him in," Luck said. "If it's the spread or whatever that crazy A-11 thing was in high school a couple of years ago, whether it's backyard football, any sport, he's the type of guy that stands out. He's just an athlete. He knows how to play. He'll be great. He always is."
Wayne needs 1,517 yards to catch former teammate Marvin Harrison's franchise record (14,580) and will enter this season with a 112-game consecutive reception streak. Since 2004, he leads the NFL with 824 catches and 11,164 yards.
But Wayne didn't return to Indianapolis after a disastrous 2-14 season in 2011 for individual glory.
At the request of head coach Chuck Pagano, a friend dating back to their days at the University of Miami, he came back to help bridge the gap between the Manning era and what the Colts hope will be new glory days with Luck.