The Colts ran five consecutive times beginning at the Niners' 47-yard line, with Bradshaw gaining 41 of his game-high 95 rushing yards on the first four carries.
The play that ended the drive was as old-school as they come, a naked bootleg on which Luck got blocks from left tackle Anthony Castonzo and wide receiver T.Y. Hilton on his way into the end zone.
The original call was for a handoff up the middle, but Hamilton added an option to it for the quarterback keeper.
"We were running so hard so well, our guys do such a great job that they have to respect Ahmad, (fullback) Stanley Havili," Luck said. "We were fortunate that T.Y. did a great job of getting the corner out of there."
After the touchdown, the defense took over. A secondary that blanketed San Francisco's receivers all afternoon again forced Kaepernick to hold onto the ball in the pocket. Freeman came blitzing in through the middle of the offensive line and knocked the ball free from the quarterback. Fellow inside linebacker Kavell Conner — making his first appearance of the season — recovered it, and the Colts had their statement win.
In Indianapolis, there's hope this is just the beginning.
"Our guys went out there with a chip on their shoulder," Pagano said. "You know why they had a chip on their shoulder and why they played — I mean, they're going to play week in and week out — but to see a locker room like that and a plane full of smiling faces and to be able to go do something that nobody thought we could go do, pretty gratifying. So really happy for all those guys, but again, we got to put that one behind us. 24-hour rule is in effect. This one is over, and we already started our preparation on Jacksonville."