And that's just one matchup among the 11 when Indianapolis has the football that will help determine the game.
The Colts have done well with a hurry-up offense early in recent weeks, but Hamilton expects the New England crowd to be a factor and make things difficult Saturday. That doesn't mean Indianapolis will go away from the no-huddle approach.
It's just another example of the many and varied ways in which the offensive coordinator's decisions will impact the contest. One thing is certain, Hamilton will not limit the options at Luck's disposal.
"We've said since Day 1, there's no can't-dos," he said. "Now is the time for us to let our hair down and let it all hang out. We're not saving plays. We're not saving any of our bullets, should I say. We got to be ready to do whatever we need to to score touchdowns."