But it's never a good idea to take anything for granted in the NFL.
A year ago at this time, Kaepernick was a backup to Alex Smith and the Colts still were a popular pick to finish with the league's worst record. Nothing was expected of the Niners quarterback or Indianapolis' franchise last season.
Kaepernick's 10th career start ended up coming in Super Bowl XLVII, and the Colts wound up as one of the best stories in the NFL after rallying behind leukemia-stricken head coach Chuck Pagano and earning an unlikely AFC wild card berth.
The odds literally and figuratively are stacked against Indianapolis on Sunday.
Of course, that's when this version of the Colts has done some of its best work.