Wilson had one final chance to pull out the comeback win. But he was hit hard by Jerrell Freeman on a fourth-and-15 attempt from his own 37-yard line, and the pass was intercepted by Darius Butler to seal the win with 1:23 to play.
The game goes down as Luck's ninth fourth-quarter comeback victory in 21 starts, and with Tennessee's loss to Kansas City the Colts are alone in first place in the AFC South for the first time since 2010.
"We'd lost our last home game," Luck said of a 24-20 decision against the Miami Dolphins three weeks ago. "To get back on track at home, we take a lot of pride in that. Maybe there's something special about the close ones. A win is a win. I'm sure you ask every guy in the locker room, and they're happy with a win."