If Houston stays put, it likely will choose either South Carolina defensive end Jadeveon Clowney or Buffalo outside linebacker Khalil Mack. Either man could form a terrorizing tandem with 2012 NFL Defensive Player of the Year J.J. Watt to make life difficult on Colts quarterback Andrew Luck.
AFC South rivals Jacksonville (third overall) and Tennessee (11th) also are in position to add elite talent in Thursday's opening round while Indianapolis watches from the sideline.
But Grigson's taking a big-picture approach, including due diligence on players expected to be available after the seven-round draft comes to an end on Saturday.
"The hay's in the barn," he said. "We're not going to sit here and create paralysis by analysis. We're looking at different avenues on how we can be productive on draft day with just five picks. I think after the draft, with the depth of this draft, I feel that's really an area to really target. We're going to really streamline that process, go and try to get those guys we covet that are still sitting on that front board of ours and go after them guns blazing to hopefully create that top 61-man roster with the practice squad."
The Colts' needs include a starting safety to replace Antoine Bethea opposite LaRon Landry, depth along the interior offensive line and at cornerback, an additional pass rushing threat and possibly a kick returner.
But the team won't rule any position out, with the obvious exception of quarterback.
Grigson is constantly preparing for the future with an eye on winning now. Head coach Chuck Pagano has made no secret of the fact his goal is to win Super Bowl XLIX, and the franchise is hoping to bounce back from a draft that produced little immediate impact last year.