But the Pacers rallied with an 11-2 run to take a 28-26 lead. Anthony bailed out the Knicks with a buzzer-beating 3-pointer to make it 31-30 after one.
Indiana seized control with an 11-1 spurt midway through the second quarter and pulled away late in the first half with a 16-7 run. That made it 63-48 at halftime.
George opened the second half by scoring 10 points in a 15-8 spurt, which made it 78-56, and Stephenson closed it out as the Knicks couldn't get closer than 16 the rest of the way.
"We understand how good we are when we run," George said. "I think that's the best way to put and the biggest way to look at it."
NOTES: Kenyon Martin left in the second quarter and Amare Stoudemire followed him to the locker room in the third quarter. Both had sprained left ankles and did not return. ... Former Pacers All-Star Metta World Peace was inactive in New York's only regular-season game in Indianapolis. ... Fans chanted "Reg-gie, Reg-gie" when former Pacers star turned TV analyst Reggie Miller was shown on the overhead screen during the fourth quarter. ... Indiana has won four straight home games against the Knicks.